Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8NA56
UPID:
TTC29_HUMAN
Alternative names:
Protein TBPP2A; Testis development protein NYD-SP14
Alternative UPACC:
Q8NA56; A4GU95; Q9BXB6
Background:
Tetratricopeptide repeat protein 29, also known as Protein TBPP2A or Testis development protein NYD-SP14, plays a crucial role in reproductive biology. It is an axonemal protein essential for the assembly of axonemal and peri-axonemal structures, directly influencing flagella assembly and sperm motility.
Therapeutic significance:
Given its pivotal role in sperm motility, Tetratricopeptide repeat protein 29 is closely associated with Spermatogenic failure 42, a condition marked by severe infertility due to sperm motility issues. Understanding the role of Tetratricopeptide repeat protein 29 could open doors to potential therapeutic strategies for treating infertility disorders.