Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8NC56
UPID:
LEMD2_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NC56; B4DVH5; E7EVT2; Q5T972; Q5T974
Background:
LEM domain-containing protein 2 plays a pivotal role in nuclear structure organization, ensuring the integrity of the nuclear envelope and its reformation post-mitosis. It acts as a transmembrane adapter for ESCRT, aiding in ESCRT-mediated nuclear envelope reformation. This protein is crucial in organizing heterochromatin associated with the nuclear envelope and maintaining its organization under mechanical stress, highlighting its significance in cellular architecture.
Therapeutic significance:
LEM domain-containing protein 2 is implicated in Cataract 46, juvenile-onset, with or without arrhythmic cardiomyopathy, and Marbach-Rustad progeroid syndrome. Understanding the role of LEM domain-containing protein 2 could open doors to potential therapeutic strategies for these conditions, emphasizing the importance of targeted research in uncovering novel treatments.