Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8NC60
UPID:
NOA1_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NC60; Q8N7L6; Q9BSQ9
Background:
Nitric oxide-associated protein 1 plays a pivotal role in cellular energy production and survival, primarily through its involvement in the regulation of mitochondrial protein translation and respiration. It acts as a crucial component in mitochondria-mediated cell death pathways and may serve as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Its ability to bind GTP underscores its significance in cellular metabolic processes.
Therapeutic significance:
Understanding the role of Nitric oxide-associated protein 1 could open doors to potential therapeutic strategies. Its central role in mitochondrial function and cell death pathways makes it a promising target for interventions in diseases characterized by mitochondrial dysfunction or aberrant cell death.