Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8NCM2
UPID:
KCNH5_HUMAN
Alternative names:
Ether-a-go-go potassium channel 2; Voltage-gated potassium channel subunit Kv10.2
Alternative UPACC:
Q8NCM2; C9JP98
Background:
Potassium voltage-gated channel subfamily H member 5, also known as Ether-a-go-go potassium channel 2 and Voltage-gated potassium channel subunit Kv10.2, plays a crucial role in cellular electrophysiology. This protein forms a pore for potassium ions, facilitating an outward rectifying current that is essential for the electrical activity of cells. Its activity can be influenced by cAMP levels and the assembly of subunits, indicating a complex regulation mechanism.
Therapeutic significance:
Understanding the role of Potassium voltage-gated channel subfamily H member 5 could open doors to potential therapeutic strategies. Its pivotal function in modulating cellular electrical activity makes it a promising target for drug discovery, aiming to treat diseases associated with electrical dysregulation.