Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8NDM7
UPID:
CFA43_HUMAN
Alternative names:
WD repeat-containing protein 96
Alternative UPACC:
Q8NDM7; Q8N9Z8; Q8NE17; Q9H085; Q9H5W3
Background:
Cilia- and flagella-associated protein 43, also known as WD repeat-containing protein 96, plays a crucial role in the organization and function of sperm flagellum axoneme. This protein is pivotal for the proper beating frequency of motile cilia in the respiratory tract, suggesting its significant role in both reproductive and respiratory health.
Therapeutic significance:
The protein is linked to Spermatogenic failure 19, characterized by defects in spermatogenesis leading to infertility, and Hydrocephalus, normal pressure, 1, marked by progressive neurological decline. Targeting this protein could offer novel therapeutic avenues for treating these conditions.