Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8NEM8
UPID:
CBPC3_HUMAN
Alternative names:
ATP/GTP-binding protein-like 3; Protein deglutamylase CCP3
Alternative UPACC:
Q8NEM8; B7Z827; Q9H965
Background:
Cytosolic carboxypeptidase 3, also known as ATP/GTP-binding protein-like 3 and Protein deglutamylase CCP3, is a pivotal enzyme in cellular function. It specializes in the deglutamylation of tubulin and various non-tubulin proteins, including MYLK, by removing polyglutamate side chains. This process is crucial for the regulation of tubulin, a key component of the cytoskeleton, affecting cell shape, division, and motility.
Therapeutic significance:
Understanding the role of Cytosolic carboxypeptidase 3 could open doors to potential therapeutic strategies. Its unique enzymatic activity in protein modification and cellular regulation highlights its potential as a target in diseases where these processes are dysregulated.