Focused On-demand Library for Interleukin-27 subunit alpha

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.

From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Several key aspects differentiate our library:

Receptor.AI compiles an all-encompassing dataset on the target protein, including historical experiments, literature data, known ligands, and structural insights, maximising the chances of prioritising the most pertinent compounds.
The platform employs state-of-the-art molecular simulations to identify potential binding sites, ensuring the focused library is primed for discovering allosteric inhibitors and binders of concealed pockets.
Over 50 customisable AI models, thoroughly evaluated in various drug discovery endeavours and research projects, make Receptor.AI both efficient and accurate. This technology is integral to the development of our focused libraries.
In addition to generating focused libraries, Receptor.AI offers a full range of services and solutions for every step of preclinical drug discovery, with a pricing model based on success, thereby reducing risk and promoting joint project success.

partner

Reaxense

upacc

Q8NEV9

UPID:

IL27A_HUMAN

Alternative names:

Interleukin-30; p28

Alternative UPACC:

Q8NEV9; A0N0L2; Q6P676

Background:

Interleukin-27 subunit alpha, also known as Interleukin-30 or p28, plays a pivotal role in innate immunity. It forms part of the IL-27 cytokine, working alongside EBI3. This heterodimeric cytokine exhibits both pro- and anti-inflammatory properties, influencing T-helper cell development, T-cell proliferation, and B-cell isotype switching. It targets various immune cells, including CD4 T-helper cells, driving their differentiation into TH1, TH2, and TH17 cells, and plays a crucial role in the early phase of TH1 response.

Therapeutic significance:

Understanding the role of Interleukin-27 subunit alpha could open doors to potential therapeutic strategies. Its ability to regulate immune responses, suppress pro-inflammatory cytokines, and exhibit antitumor and antiangiogenic activities highlights its therapeutic potential in managing immune-related disorders and cancer.