Focused On-demand Library for Interleukin-27 subunit alpha

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.

Our library stands out due to several important features:

The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.

partner

Reaxense

upacc

Q8NEV9

UPID:

IL27A_HUMAN

Alternative names:

Interleukin-30; p28

Alternative UPACC:

Q8NEV9; A0N0L2; Q6P676

Background:

Interleukin-27 subunit alpha, also known as Interleukin-30 or p28, plays a pivotal role in innate immunity. It forms part of the IL-27 cytokine, working alongside EBI3. This heterodimeric cytokine exhibits both pro- and anti-inflammatory properties, influencing T-helper cell development, T-cell proliferation, and B-cell isotype switching. It targets various immune cells, including CD4 T-helper cells, driving their differentiation into TH1, TH2, and TH17 cells, and plays a crucial role in the early phase of TH1 response.

Therapeutic significance:

Understanding the role of Interleukin-27 subunit alpha could open doors to potential therapeutic strategies. Its ability to regulate immune responses, suppress pro-inflammatory cytokines, and exhibit antitumor and antiangiogenic activities highlights its therapeutic potential in managing immune-related disorders and cancer.