Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
This process includes extensive molecular simulations of the receptor in its native membrane environment, along with ensemble virtual screening that accounts for its conformational mobility. In the case of dimeric or oligomeric receptors, the entire functional complex is modelled, identifying potential binding pockets on and between the subunits to encompass all possible mechanisms of action.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8NFJ6
UPID:
PKR2_HUMAN
Alternative names:
G-protein coupled receptor 73-like 1; G-protein coupled receptor I5E; GPR73b; GPRg2
Alternative UPACC:
Q8NFJ6; A5JUU1; Q2M3C0; Q5TDY1; Q9NTT0
Background:
Prokineticin receptor 2, known by names such as G-protein coupled receptor 73-like 1 and GPR73b, plays a pivotal role in cellular signaling. It is exclusively coupled to the G(q) subclass of heteromeric G proteins, leading to calcium mobilization, phosphoinositide turnover, and activation of p44/p42 mitogen-activated protein kinase.
Therapeutic significance:
Linked to Hypogonadotropic hypogonadism 3 with or without anosmia, Prokineticin receptor 2's understanding could pave the way for novel therapeutic strategies. Its involvement in gonadotropin-releasing hormone deficiency highlights its potential in treating reproductive and non-reproductive phenotypes, including anosmia and sensorineural hearing loss.