Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8NFQ8
UPID:
TOIP2_HUMAN
Alternative names:
Lumenal domain-like LAP1
Alternative UPACC:
Q8NFQ8
Background:
Torsin-1A-interacting protein 2, also known as Lumenal domain-like LAP1, plays a crucial role in maintaining endoplasmic reticulum integrity. It is pivotal in regulating the distribution of TOR1A across the endoplasmic reticulum and the nuclear envelope, in addition to inducing ATPase activity in TOR1A, TOR1B, and TOR3A.
Therapeutic significance:
Understanding the role of Torsin-1A-interacting protein 2 could open doors to potential therapeutic strategies.