Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8NHR7
UPID:
TERB2_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NHR7
Background:
Telomere repeats-binding bouquet formation protein 2 plays a pivotal role in meiosis, specifically in telomere attachment to the nucleus inner membrane. This process is essential for homologous pairing and synapsis, facilitated by the MAJIN-TERB1-TERB2 complex, which the protein is a component of. The complex's interaction with telomeric DNA and the shelterin/telosome complex is crucial for telomere cap exchange and the protection of telomeric chromosomes.
Therapeutic significance:
The protein's involvement in Spermatogenic failure 59, a male infertility disorder due to sperm maturation arrest, highlights its potential as a target for therapeutic intervention. Understanding the role of Telomere repeats-binding bouquet formation protein 2 could open doors to potential therapeutic strategies.