Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8NI99
UPID:
ANGL6_HUMAN
Alternative names:
Angiopoietin-like protein 6; Angiopoietin-related growth factor; Angiopoietin-related protein 5
Alternative UPACC:
Q8NI99; A5PKV7; Q9BZZ0
Background:
Angiopoietin-related protein 6, also known as Angiopoietin-like protein 6, plays a crucial role in the wound healing process by promoting epidermal proliferation, remodeling, and regeneration. It enhances the chemotactic activity of endothelial cells and stimulates neovascularization. Furthermore, it may counteract obesity and insulin resistance induced by a high-fat diet through increased energy expenditure.
Therapeutic significance:
Understanding the role of Angiopoietin-related protein 6 could open doors to potential therapeutic strategies in enhancing wound healing, combating obesity, and improving insulin sensitivity.