Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8TAF8
UPID:
LHPL5_HUMAN
Alternative names:
Lipoma HMGIC fusion partner-like 5 protein; Tetraspan membrane protein of hair cell stereocilia
Alternative UPACC:
Q8TAF8; B3KX66
Background:
LHFPL tetraspan subfamily member 5 protein, also known as Lipoma HMGIC fusion partner-like 5 protein and Tetraspan membrane protein of hair cell stereocilia, plays a crucial role in the inner ear's mechanotransduction machinery. It functionally couples PCDH15 to the transduction channel, regulating channel conductance and facilitating fast channel adaptation.
Therapeutic significance:
Linked to Deafness, autosomal recessive, 67, this protein's malfunctioning due to genetic variants underscores its potential as a target for therapeutic intervention in sensorineural hearing loss.