Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8TAQ2
UPID:
SMRC2_HUMAN
Alternative names:
BRG1-associated factor 170; SWI/SNF complex 170 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
Alternative UPACC:
Q8TAQ2; F8VTJ5; Q59GV3; Q92923; Q96E12; Q96GY4
Background:
SWI/SNF complex subunit SMARCC2, also known as BRG1-associated factor 170, plays a pivotal role in chromatin remodeling. It is a component of the SWI/SNF chromatin remodeling complexes, influencing transcriptional activation and repression by altering DNA-nucleosome topology. This protein is crucial for the transition from proliferating neural stem cells to postmitotic neurons, highlighting its importance in neural development.
Therapeutic significance:
Given its involvement in Coffin-Siris syndrome 8, characterized by intellectual disability and dysmorphic features, understanding the role of SWI/SNF complex subunit SMARCC2 could open doors to potential therapeutic strategies. Its function in chromatin remodeling and gene expression regulation makes it a promising target for addressing the genetic underpinnings of this syndrome.