AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for POC1 centriolar protein homolog B

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We use our state-of-the-art dedicated workflow for designing focused libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.

Our library stands out due to several important features:

  • The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
  • Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
  • Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
  • Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.

partner

Reaxense

upacc

Q8TC44

UPID:

POC1B_HUMAN

Alternative names:

Pix1; Proteome of centriole protein 1B; WD repeat-containing protein 51B

Alternative UPACC:

Q8TC44; G3V1X0

Background:

POC1 centriolar protein homolog B (POC1B) is pivotal in centriole assembly and stability, playing a crucial role in ciliogenesis, centriole duplication, and length control. It works alongside POC1A to maintain centriole integrity, ensuring proper mitotic spindle formation. POC1B is essential for primary cilia formation, ciliary length, cell proliferation, and maintaining retinal integrity.

Therapeutic significance:

POC1B's involvement in Cone-rod dystrophy 20, a retinal dystrophy leading to severe vision loss, underscores its therapeutic potential. Understanding POC1B's role could pave the way for innovative treatments targeting retinal degenerative diseases.

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