Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8TC94
UPID:
ACTL9_HUMAN
Alternative names:
-
Alternative UPACC:
Q8TC94; A8K893; Q6X960
Background:
Actin-like protein 9, encoded by the gene with accession number Q8TC94, is pivotal in male fertility, specifically influencing the structural integrity of sperm heads. Its primary function involves the fusion of proacrosomal vesicles and the formation of the perinuclear theca in the testis, underscoring its specialized role in reproductive biology.
Therapeutic significance:
Linked to Spermatogenic failure 53, a disorder marked by infertility due to oocyte activation failure and sperm head anomalies, Actin-like protein 9's study could illuminate new pathways for infertility treatments. Understanding the role of Actin-like protein 9 could open doors to potential therapeutic strategies.