Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8TCB7
UPID:
METL6_HUMAN
Alternative names:
Methyltransferase-like protein 6
Alternative UPACC:
Q8TCB7; Q96LU4
Background:
The tRNA N(3)-methylcytidine methyltransferase METTL6, also known as Methyltransferase-like protein 6, plays a crucial role in the post-transcriptional modification of tRNA. It specifically mediates the N(3)-methylcytidine modification of residue 32 in the anticodon loop of tRNA(Ser), a process essential for the accurate translation of the genetic code into proteins. This modification is facilitated through its interaction with SARS1/SerRS, highlighting a complex regulatory mechanism.
Therapeutic significance:
Understanding the role of tRNA N(3)-methylcytidine methyltransferase METTL6 could open doors to potential therapeutic strategies. Its precise function in tRNA modification suggests a foundational role in protein synthesis, offering a novel angle for targeting diseases at the genetic translation level.