Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8TCJ2
UPID:
STT3B_HUMAN
Alternative names:
Source of immunodominant MHC-associated peptides homolog
Alternative UPACC:
Q8TCJ2; Q96JZ4; Q96KY7
Background:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B plays a pivotal role in protein N-glycosylation, a process critical for protein folding and stability. It acts as the catalytic subunit within the oligosaccharyl transferase complex, facilitating the transfer of glycan chains to nascent proteins, essential for their proper function and localization. Its activity is crucial in both co- and post-translational modifications, impacting a wide array of biological processes.
Therapeutic significance:
Given its central role in glycoprotein biosynthesis, STT3B's dysfunction is linked to Congenital disorder of glycosylation 1X, manifesting in severe developmental and systemic anomalies. Understanding the role of STT3B could open doors to potential therapeutic strategies, offering hope for targeted interventions in glycosylation disorders and enhancing our approach to precision medicine.