Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8TDB8
UPID:
GTR14_HUMAN
Alternative names:
Glucose transporter type 14
Alternative UPACC:
Q8TDB8; B3KVB5; B3KWW7; B7Z844; B7ZAC3; Q6UY84; Q8TDB9
Background:
Solute carrier family 2, facilitated glucose transporter member 14, also known as Glucose transporter type 14, plays a crucial role in cellular metabolism by mediating the transport of glucose and dehydroascorbate across the cell membrane. This protein's ability to facilitate hexose transport is vital for maintaining glucose homeostasis and antioxidant defense.
Therapeutic significance:
Understanding the role of Solute carrier family 2, facilitated glucose transporter member 14 could open doors to potential therapeutic strategies. Its involvement in glucose transport and cellular antioxidant mechanisms positions it as a key target for addressing metabolic disorders and enhancing cellular resilience to oxidative stress.