Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for receptors.
Fig. 1. The sreening workflow of Receptor.AI
The method involves detailed molecular simulations of the receptor in its native membrane environment, with ensemble virtual screening focusing on its conformational mobility. When dealing with dimeric or oligomeric receptors, the whole functional complex is modelled, and the tentative binding pockets on and between the subunits are established to address all possible mechanisms of action.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8TDU9
UPID:
RL3R2_HUMAN
Alternative names:
G-protein coupled receptor 100; G-protein coupled receptor GPCR142; Insulin-like peptide INSL5 receptor; Relaxin family peptide receptor 4
Alternative UPACC:
Q8TDU9; B0M0L4; Q3MJB1; Q8NGZ8
Background:
Relaxin-3 receptor 2, known as G-protein coupled receptor 100, plays a pivotal role in cellular communication, acting as a high affinity receptor for INSL5 and RLN3/relaxin-3, alongside bradykinin and kallidin. Its ability to inhibit cAMP accumulation highlights its significance in signal transduction pathways.
Therapeutic significance:
Understanding the role of Relaxin-3 receptor 2 could open doors to potential therapeutic strategies. Its involvement in key signaling pathways suggests its potential as a target for drug discovery, aiming to modulate its activity for therapeutic benefits.