Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8TE76
UPID:
MORC4_HUMAN
Alternative names:
Zinc finger CW-type coiled-coil domain protein 2; Zinc finger CW-type domain protein 4
Alternative UPACC:
Q8TE76; A1YR23; A1YR24; H7BXF1; Q5JUK7; Q96MZ2; Q9HAI7
Background:
The MORC family CW-type zinc finger protein 4, also known as Zinc finger CW-type coiled-coil domain protein 2 and Zinc finger CW-type domain protein 4, plays a crucial role in histone methylation. It specifically binds to various methylated states of 'Lys-4' on histone H3, with a preference order of H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0. This binding ability underscores its significance in epigenetic regulation.
Therapeutic significance:
Understanding the role of MORC family CW-type zinc finger protein 4 could open doors to potential therapeutic strategies. Its involvement in histone methylation positions it as a key player in epigenetic mechanisms, which are crucial for gene expression regulation and have implications in numerous diseases.