Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8TE99
UPID:
PXYP1_HUMAN
Alternative names:
Acid phosphatase-like protein 2; Xylosyl phosphatase; epididymis luminal protein 124
Alternative UPACC:
Q8TE99; D3DNF5; Q49AJ2; W0TR04
Background:
2-phosphoxylose phosphatase 1, also known as Acid phosphatase-like protein 2, Xylosyl phosphatase, and epididymis luminal protein 124, plays a crucial role in the biosynthesis of glycosaminoglycans (GAGs). It is responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans, a key step in regulating the amount of mature GAG chains. These sulfated GAGs, including heparan sulfate and chondroitin sulfate, are essential for various biological processes.
Therapeutic significance:
Understanding the role of 2-phosphoxylose phosphatase 1 could open doors to potential therapeutic strategies.