Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8TED1
UPID:
GPX8_HUMAN
Alternative names:
-
Alternative UPACC:
Q8TED1
Background:
Probable glutathione peroxidase 8 plays a crucial role in protecting cells from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides, and organic hydroperoxide by glutathione. This enzyme is part of a family of glutathione peroxidases, which are critical for cellular antioxidant defenses.
Therapeutic significance:
Understanding the role of Probable glutathione peroxidase 8 could open doors to potential therapeutic strategies. Its function in cellular protection against oxidative stress suggests its involvement in diseases where oxidative damage is a key factor, offering a promising target for therapeutic intervention.