Focused On-demand Library for GPI ethanolamine phosphate transferase 3

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

We employ our advanced, specialised process to create targeted libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.







Alternative names:

Phosphatidylinositol-glycan biosynthesis class O protein

Alternative UPACC:

Q8TEQ8; B1AML3; Q6P154; Q6UX80; Q8TDS8; Q96CS9; Q9BVN9; Q9Y4B0


GPI ethanolamine phosphate transferase 3, also known as Phosphatidylinositol-glycan biosynthesis class O protein, plays a crucial role in glycosylphosphatidylinositol-anchor biosynthesis. This enzyme is responsible for transferring ethanolamine phosphate to the GPI third mannose, facilitating the linkage of GPI-anchor to proteins' C-terminus via an amide bond.

Therapeutic significance:

The protein is implicated in Hyperphosphatasia with impaired intellectual development syndrome 2, a condition marked by intellectual disability, facial dysmorphism, and elevated serum alkaline phosphatase. Understanding the role of GPI ethanolamine phosphate transferase 3 could open doors to potential therapeutic strategies for this genetic disorder.

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