Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8WUH1
UPID:
CHUR_HUMAN
Alternative names:
-
Alternative UPACC:
Q8WUH1; A0A0C4DGJ7; B3KQ81; G3V1X3; G3V214; Q9H3K7
Background:
Protein Churchill plays a pivotal role in neural development, acting as a transcriptional activator within the FGF signaling pathway. Its unique function in regulating cell movement, although not directly binding to DNA, positions it as a key player in cellular dynamics.
Therapeutic significance:
Understanding the role of Protein Churchill could open doors to potential therapeutic strategies. Its involvement in critical pathways of neural development highlights its potential as a target for therapeutic intervention in neurological disorders.