AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for Soluble calcium-activated nucleotidase 1

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

Our top-notch dedicated system is used to design specialised libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Key features that set our library apart include:

  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q8WVQ1

UPID:

CANT1_HUMAN

Alternative names:

Apyrase homolog; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107

Alternative UPACC:

Q8WVQ1; B4DJ54; Q7Z2J7; Q8NG05; Q8NHP0; Q9BSD5

Background:

Soluble calcium-activated nucleotidase 1, also known as Apyrase homolog, Putative MAPK-activating protein PM09, and Putative NF-kappa-B-activating protein 107, exhibits a calcium-dependent nucleotidase activity with a preference for UDP. This enzyme plays a crucial role in proteoglycan synthesis, impacting various biological processes.

Therapeutic significance:

Linked to diseases such as Desbuquois dysplasia 1 and Epiphyseal dysplasia, multiple, 7, Soluble calcium-activated nucleotidase 1's involvement in these conditions underscores its potential as a target for therapeutic intervention. Understanding the role of Soluble calcium-activated nucleotidase 1 could open doors to potential therapeutic strategies.

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