Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8WVT3
UPID:
TPC12_HUMAN
Alternative names:
Tetratricopeptide repeat protein 15; Trafficking of membranes and mitosis
Alternative UPACC:
Q8WVT3; B3KV01; D6W4Y2; Q8WVW1; Q9Y395
Background:
Trafficking protein particle complex subunit 12, also known as Tetratricopeptide repeat protein 15, plays a crucial role in cellular processes including endoplasmic reticulum to Golgi apparatus trafficking and chromosome congression. It is essential for kinetochore assembly and stability, facilitating the recruitment of CENPE to kinetochores.
Therapeutic significance:
Linked to the progressive encephalopathy with brain atrophy and spasticity, understanding the role of Trafficking protein particle complex subunit 12 could open doors to potential therapeutic strategies.