Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8WW22
UPID:
DNJA4_HUMAN
Alternative names:
-
Alternative UPACC:
Q8WW22; E9PDM9; Q6AW87; Q8N5Z4; Q8N7P2
Background:
DnaJ homolog subfamily A member 4 plays a crucial role in the molecular chaperone system, assisting in protein folding and stabilization. Its involvement in cellular stress responses ensures proper protein configuration and functionality, safeguarding against misfolded protein aggregation.
Therapeutic significance:
Understanding the role of DnaJ homolog subfamily A member 4 could open doors to potential therapeutic strategies. Its pivotal function in protein homeostasis and stress response mechanisms positions it as a key target for modulating disease pathways related to protein misfolding.