Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8WXD5
UPID:
GEMI6_HUMAN
Alternative names:
SIP2
Alternative UPACC:
Q8WXD5; B2RDP8; Q53SI5; Q8WVB4; Q9H5G6
Background:
Gem-associated protein 6 (SIP2) is pivotal in cellular pre-mRNA splicing, facilitating the assembly of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome. This process involves the formation of a heptameric protein ring, crucial for the core snRNP assembly, highlighting its integral role in gene expression regulation.
Therapeutic significance:
Understanding the role of Gem-associated protein 6 could open doors to potential therapeutic strategies. Its critical function in mRNA splicing underscores its potential as a target for interventions in diseases where gene expression is disrupted.