Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8WXH4
UPID:
ASB11_HUMAN
Alternative names:
-
Alternative UPACC:
Q8WXH4; E9PEN1; Q3SYC4; Q7Z667
Background:
Ankyrin repeat and SOCS box protein 11 plays a crucial role in cellular processes as a potential component of the SCF-like ECS E3 ubiquitin-protein ligase complex. This complex is pivotal for the ubiquitination and subsequent proteasomal degradation of target proteins, regulating protein turnover and function.
Therapeutic significance:
Understanding the role of Ankyrin repeat and SOCS box protein 11 could open doors to potential therapeutic strategies. Its involvement in protein degradation pathways highlights its importance in maintaining cellular homeostasis and presents a novel target for drug discovery.