Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8WZ04
UPID:
TOMT_HUMAN
Alternative names:
Catechol O-methyltransferase 2; Protein LRTOMT2
Alternative UPACC:
Q8WZ04; B7Z816
Background:
Transmembrane O-methyltransferase, also known as Catechol O-methyltransferase 2 or Protein LRTOMT2, plays a crucial role in the inactivation of catecholamine neurotransmitters and catechol hormones through O-methylation. It is essential for auditory function and is a key component of the cochlear hair cell's mechanotransduction machinery, involved in the assembly of the asymmetric tip-link complex and transportation of TMC1 and TMC2 proteins into the hair cells' stereocilia.
Therapeutic significance:
The protein's mutation is linked to Deafness, autosomal recessive, 63, a form of non-syndromic sensorineural hearing loss. Understanding the role of Transmembrane O-methyltransferase could open doors to potential therapeutic strategies for hearing loss.