Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q92523
UPID:
CPT1B_HUMAN
Alternative names:
Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1B; Carnitine palmitoyltransferase I-like protein
Alternative UPACC:
Q92523; B7Z4U4; B7Z5T8; E9PCP2; Q13389; Q99655; Q9BY90
Background:
Carnitine O-palmitoyltransferase 1, muscle isoform (CPT1B), also known as Carnitine palmitoyltransferase I-like protein, plays a pivotal role in fatty acid oxidation by facilitating the transport of long-chain fatty acids into the mitochondria. Its alternative names include Carnitine O-palmitoyltransferase I, muscle isoform, and Carnitine palmitoyltransferase 1B, highlighting its specific isoform and function in muscle tissues.
Therapeutic significance:
Understanding the role of Carnitine O-palmitoyltransferase 1, muscle isoform could open doors to potential therapeutic strategies. Its critical function in energy metabolism makes it a key target for addressing metabolic disorders and enhancing muscle function.