Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q92581
UPID:
SL9A6_HUMAN
Alternative names:
Na(+)/H(+) exchanger 6; Solute carrier family 9 member 6
Alternative UPACC:
Q92581; A6NIQ9; A8K160; B4DU30; B7ZAE0; Q3ZCW7; Q5JPP8; Q5JPP9; Q86VS0; Q8WYK8
Background:
Sodium/hydrogen exchanger 6 (SLC9A6), also known as Na(+)/H(+) exchanger 6, plays a pivotal role in regulating endosomal pH by mediating the exchange of endosomal luminal H(+) for cytosolic Na(+) or K(+). This action limits luminal acidification, essential for endosome maturation and trafficking. Furthermore, SLC9A6 is crucial for neurodevelopment, influencing synaptic development and plasticity, and maintains cell polarity by modulating intravesicular pH.
Therapeutic significance:
SLC9A6's involvement in Intellectual developmental disorder, X-linked, syndromic, Christianson type, characterized by intellectual disability, epilepsy, ataxia, and microcephaly, underscores its therapeutic significance. Understanding SLC9A6's role could unveil novel therapeutic strategies for managing this syndrome and potentially other neurodevelopmental disorders.