Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q92820
UPID:
GGH_HUMAN
Alternative names:
Conjugase; GH; Gamma-Glu-X carboxypeptidase
Alternative UPACC:
Q92820
Background:
Gamma-glutamyl hydrolase, known alternatively as Conjugase, GH, and Gamma-Glu-X carboxypeptidase, plays a crucial role in the metabolism of pteroylpolyglutamates. It hydrolyzes the polyglutamate sidechains of these compounds, progressively removing gamma-glutamyl residues to yield folic acid and free glutamate. This enzymatic activity is essential for the bioavailability of dietary pteroylpolyglutamates and the metabolism of antifolates.
Therapeutic significance:
Understanding the role of Gamma-glutamyl hydrolase could open doors to potential therapeutic strategies. Its pivotal function in the metabolism of folates and antifolates highlights its importance in nutritional science and pharmacology, suggesting avenues for intervention in diseases where folate metabolism is implicated.