Focused On-demand Library for Proprotein convertase subtilisin/kexin type 5

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our top-notch dedicated system is used to design specialised libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.

Our library stands out due to several important features:

The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.

partner

Reaxense

upacc

Q92824

UPID:

PCSK5_HUMAN

Alternative names:

Proprotein convertase 5; Proprotein convertase 6; Subtilisin/kexin-like protease PC5

Alternative UPACC:

Q92824; F5H2G7; Q13527; Q96EP4

Background:

Proprotein convertase subtilisin/kexin type 5, also known as Proprotein convertase 5 and 6, is a serine endoprotease pivotal in processing proproteins by cleavage at paired basic amino acids, adhering to the RXXX[KR]R consensus motif. It plays a crucial role in both constitutive and regulated secretory pathways, significantly impacting pregnancy establishment through the activation of factors like BMP2, CALD1, and alpha-integrins.

Therapeutic significance:

Understanding the role of Proprotein convertase subtilisin/kexin type 5 could open doors to potential therapeutic strategies, offering insights into novel treatment avenues for conditions where its function is pivotal.