Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q92830
UPID:
KAT2A_HUMAN
Alternative names:
General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; Histone glutaryltransferase KAT2A; Histone succinyltransferase KAT2A; Lysine acetyltransferase 2A; STAF97
Alternative UPACC:
Q92830; Q8N1A2; Q9UCW1
Background:
Histone acetyltransferase KAT2A, also known as General control of amino acid synthesis protein 5-like 2, plays a pivotal role in epigenetic transcription activation through its diverse enzymatic activities. It functions as an acetyltransferase, glutaryltransferase, succinyltransferase, or malonyltransferase, impacting histone modifications and non-histone protein acetylation. This protein is crucial in processes like memory consolidation, T-cell activation, and embryonic stem cell pluripotency.
Therapeutic significance:
Understanding the role of Histone acetyltransferase KAT2A could open doors to potential therapeutic strategies. Its involvement in critical cellular processes and epigenetic regulation highlights its potential as a target in diseases where these pathways are dysregulated.