Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q92979
UPID:
NEP1_HUMAN
Alternative names:
18S rRNA (pseudouridine(1248)-N1)-methyltransferase; 18S rRNA Psi1248 methyltransferase; Nucleolar protein EMG1 homolog; Protein C2f; Ribosome biogenesis protein NEP1
Alternative UPACC:
Q92979; O00675; O00726
Background:
Ribosomal RNA small subunit methyltransferase NEP1, also known as 18S rRNA Psi1248 methyltransferase, plays a pivotal role in ribosome biogenesis. It is a S-adenosyl-L-methionine-dependent enzyme that specifically methylates pseudouridine at position 1248 in 18S rRNA, a modification crucial for the production of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine. This protein is integral to the small subunit (SSU) processome, facilitating the assembly of ribosomal protein S19 and ensuring the proper formation of pre-ribosomes.
Therapeutic significance:
The association of Ribosomal RNA small subunit methyltransferase NEP1 with Bowen-Conradi syndrome, a condition marked by severe developmental anomalies and early infant mortality, underscores its clinical importance. Understanding the role of this protein could open doors to potential therapeutic strategies aimed at mitigating the effects of this syndrome.