Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q969F2
UPID:
NKD2_HUMAN
Alternative names:
-
Alternative UPACC:
Q969F2; Q96EK8; Q9BSN0
Background:
Protein naked cuticle homolog 2 plays a pivotal role in the regulation of the Wnt signaling pathways, crucial for cell development and polarity. It acts as a cell autonomous antagonist of the canonical Wnt pathway and may activate an alternative pathway influencing planar cell polarity. This protein is also essential for the processing and targeting of TGFA to the basolateral membrane in epithelial cells.
Therapeutic significance:
Understanding the role of Protein naked cuticle homolog 2 could open doors to potential therapeutic strategies.