Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q969N2
UPID:
PIGT_HUMAN
Alternative names:
Phosphatidylinositol-glycan biosynthesis class T protein
Alternative UPACC:
Q969N2; B2RND5; B7Z3N1; B7Z7I8; E1P622; G8JLF5; Q2NL69; Q7Z3N7; Q9BQY7; Q9BQY8; Q9UJG6; Q9Y2Z5
Background:
The GPI transamidase component PIG-T, also known as Phosphatidylinositol-glycan biosynthesis class T protein, plays a crucial role in the post-translational modification of proteins through the addition of a glycosylphosphatidylinositol (GPI) anchor. This process is essential for the proper localization and function of various proteins on the cell surface.
Therapeutic significance:
PIG-T is implicated in Multiple congenital anomalies-hypotonia-seizures syndrome 3 and Paroxysmal nocturnal hemoglobinuria 2. These associations highlight the protein's potential as a target for therapeutic intervention in these genetic disorders, emphasizing the importance of understanding its biological mechanisms.