Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q969Q1
UPID:
TRI63_HUMAN
Alternative names:
Iris RING finger protein; Muscle-specific RING finger protein 1; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; Striated muscle RING zinc finger protein; Tripartite motif-containing protein 63
Alternative UPACC:
Q969Q1; B4DN95; Q5T2I1; Q96BD3; Q96KD9; Q9BYV4
Background:
E3 ubiquitin-protein ligase TRIM63, also known as Muscle-specific RING finger protein 1, plays a pivotal role in muscle protein regulation. It mediates ubiquitination and proteasomal degradation of various proteins, crucial under amino acid starvation. TRIM63 is instrumental in skeletal muscle protein synthesis inhibition and regulates cardiac troponin I degradation, impacting muscle atrophy, hypertrophy, and myofibril organization.
Therapeutic significance:
Understanding the role of E3 ubiquitin-protein ligase TRIM63 could open doors to potential therapeutic strategies.