Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q969Q5
UPID:
RAB24_HUMAN
Alternative names:
-
Alternative UPACC:
Q969Q5; A0A024R7N9; Q7Z4Z7
Background:
Ras-related protein Rab-24 plays a crucial role in cellular processes, potentially linked to autophagy, a vital mechanism for cellular homeostasis and survival. This protein, encoded by the gene with the UniProt accession number Q969Q5, is part of the Ras superfamily, known for its involvement in various cellular functions including cell growth, movement, and differentiation.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-24 could open doors to potential therapeutic strategies. Its involvement in autophagy-related processes suggests a significant impact on cellular health and disease prevention, making it a target of interest for drug discovery efforts.