Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96A08
UPID:
H2B1A_HUMAN
Alternative names:
Histone H2B, testis; Testis-specific histone H2B
Alternative UPACC:
Q96A08; B2R544; Q6NZ98; Q6NZA0; Q6NZA1
Background:
Histone H2B type 1-A, also known as Testis-specific histone H2B, plays a pivotal role in the transformation of nucleosomes to protamine in male germ cells, facilitating chromatin dynamics essential for DNA repair, replication, and stability. Its presence in fat cells suggests additional, yet unclear functions.
Therapeutic significance:
Understanding the role of Histone H2B type 1-A could open doors to potential therapeutic strategies.