Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96AQ7
UPID:
CIDEC_HUMAN
Alternative names:
Cell death activator CIDE-3; Cell death-inducing DFFA-like effector protein C; Fat-specific protein FSP27 homolog
Alternative UPACC:
Q96AQ7; C9JMN7; Q67DW9; Q9GZY9
Background:
Lipid transferase CIDEC, also known as Cell death activator CIDE-3, plays a pivotal role in lipid metabolism within white adipose tissue. It facilitates the formation of unilocular lipid droplets by mediating their fusion, thus promoting lipid storage over lipolysis. This process is crucial for maintaining energy balance and metabolic health. CIDEC localizes on the lipid droplet surface, engaging in atypical lipid droplet fusion through liquid-liquid phase separation and directional net neutral lipid transfer.
Therapeutic significance:
CIDEC's involvement in Lipodystrophy, familial partial, 5, a condition characterized by abnormal fat distribution and metabolic complications, underscores its therapeutic potential. Targeting CIDEC's pathway could offer novel interventions for managing lipodystrophy and related metabolic disorders, providing a promising avenue for drug discovery aimed at restoring lipid homeostasis and improving insulin sensitivity.