Focused On-demand Library for Calcium release-activated calcium channel protein 1

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our top-notch dedicated system is used to design specialised libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Several key aspects differentiate our library:

  • Receptor.AI compiles an all-encompassing dataset on the target protein, including historical experiments, literature data, known ligands, and structural insights, maximising the chances of prioritising the most pertinent compounds.
  • The platform employs state-of-the-art molecular simulations to identify potential binding sites, ensuring the focused library is primed for discovering allosteric inhibitors and binders of concealed pockets.
  • Over 50 customisable AI models, thoroughly evaluated in various drug discovery endeavours and research projects, make Receptor.AI both efficient and accurate. This technology is integral to the development of our focused libraries.
  • In addition to generating focused libraries, Receptor.AI offers a full range of services and solutions for every step of preclinical drug discovery, with a pricing model based on success, thereby reducing risk and promoting joint project success.







Alternative names:

Protein orai-1; Transmembrane protein 142A

Alternative UPACC:

Q96D31; Q3MHV3; Q6DHX2; Q96BP7; Q96K71


Calcium release-activated calcium channel protein 1, also known as Protein orai-1 and Transmembrane protein 142A, plays a crucial role in mediating Ca(2+) influx following the depletion of intracellular Ca(2+) stores. This process is activated by the Ca(2+) sensor, STIM1, and is essential for various cellular functions, including the immune response and milk secretion in mammary epithelial cells.

Therapeutic significance:

The protein's involvement in Immunodeficiency 9 and Myopathy, tubular aggregate, 2, underscores its potential as a target for therapeutic intervention. These diseases, resulting from gene variants affecting the protein, highlight its critical role in immune function and muscle pathology. Exploring therapeutic strategies targeting this protein could lead to significant advancements in treating these conditions.

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