Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96DA6
UPID:
TIM14_HUMAN
Alternative names:
DnaJ homolog subfamily C member 19
Alternative UPACC:
Q96DA6; B2R4B1; C9JBV1
Background:
Mitochondrial import inner membrane translocase subunit TIM14, also known as DnaJ homolog subfamily C member 19, plays a crucial role in mitochondrial function. It is involved in the formation of a complex with prohibitins that is essential for cardiolipin remodeling. This protein is potentially a component of the PAM complex, facilitating the translocation of proteins into the mitochondrial matrix in an ATP-dependent manner.
Therapeutic significance:
Linked to 3-methylglutaconic aciduria 5, a disorder characterized by dilated cardiomyopathy, cerebellar ataxia, and metabolic anomalies, TIM14's genetic variants highlight its therapeutic significance. Understanding the role of TIM14 could open doors to potential therapeutic strategies for treating mitochondrial disorders and related metabolic conditions.