Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96EU7
UPID:
C1GLC_HUMAN
Alternative names:
C38H2-like protein 1; Core 1 beta1,3-galactosyltransferase 2; Core 1 beta3-galactosyltransferase-specific molecular chaperone
Alternative UPACC:
Q96EU7; A8K246; Q8WWS3; Q9NZX1
Background:
C1GALT1-specific chaperone 1, also known as Core 1 beta1,3-galactosyltransferase 2, plays a crucial role in the synthesis of O-glycans in glycoproteins. This protein acts as a molecular chaperone for C1GALT1, ensuring its proper folding and stability, which is essential for the generation of the T antigen on cell surfaces.
Therapeutic significance:
The expression of the Tn antigen, facilitated by C1GALT1-specific chaperone 1, is linked to Tn polyagglutination syndrome. This condition, associated with anemia, leukopenia, or thrombocytopenia, and potentially leukemia or myelodysplastic disorders, underscores the protein's clinical relevance. Understanding its role could lead to novel therapeutic strategies for these diseases.