Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96F07
UPID:
CYFP2_HUMAN
Alternative names:
p53-inducible protein 121
Alternative UPACC:
Q96F07; A6NLT2; D3DQJ3; Q53EN5; Q9NTK4; Q9ULQ2; Q9UN29
Background:
Cytoplasmic FMR1-interacting protein 2, also known as p53-inducible protein 121, plays a crucial role in T-cell adhesion and p53/TP53-dependent apoptosis. It is a key component of the WAVE1 complex, essential for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. This protein does not bind RNA.
Therapeutic significance:
The protein is implicated in Developmental and Epileptic Encephalopathy 65 (DEE65), a severe early-onset epilepsy with neurodevelopmental impairment. Understanding the role of Cytoplasmic FMR1-interacting protein 2 could open doors to potential therapeutic strategies for DEE65.