Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96F86
UPID:
EDC3_HUMAN
Alternative names:
LSM16 homolog; YjeF N-terminal domain-containing protein 2; YjeF domain-containing protein 1
Alternative UPACC:
Q96F86; B3KPH0; D3DW61; Q9H797
Background:
Enhancer of mRNA-decapping protein 3, also known as LSM16 homolog, plays a crucial role in mRNA degradation and regulation. It binds single-stranded RNA and is pivotal in mRNA decapping, a process essential for gene expression. Additionally, it contributes to spermiogenesis and oogenesis, highlighting its importance in reproductive biology.
Therapeutic significance:
This protein's mutation is linked to Intellectual developmental disorder, autosomal recessive 50, characterized by mild intellectual disability and microcephaly. Understanding the role of Enhancer of mRNA-decapping protein 3 could open doors to potential therapeutic strategies for this disorder.