Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96FX8
UPID:
PERP_HUMAN
Alternative names:
Keratinocyte-associated protein 1; P53-induced protein PIGPC1; Transmembrane protein THW
Alternative UPACC:
Q96FX8; B2RB73; E1P590; Q8IWS3; Q8N1J6; Q8NC16; Q9H1C5; Q9H230
Background:
The p53 apoptosis effector related to PMP-22, also known as Keratinocyte-associated protein 1, P53-induced protein PIGPC1, and Transmembrane protein THW, plays a crucial role in maintaining stratified epithelial integrity. It is a component of intercellular desmosome junctions, promoting desmosome assembly and cell-cell adhesion. Additionally, it serves as an effector in the TP53-dependent apoptotic pathway, highlighting its multifaceted role in cellular integrity and apoptosis.
Therapeutic significance:
Linked to Erythrokeratodermia variabilis et progressiva 7 and Olmsted syndrome 2, this protein's involvement in skin disorders underscores its therapeutic potential. Understanding the role of p53 apoptosis effector related to PMP-22 could open doors to potential therapeutic strategies for these genodermatoses, offering hope for targeted treatments.