Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96G25
UPID:
MED8_HUMAN
Alternative names:
Activator-recruited cofactor 32 kDa component; Mediator complex subunit 8
Alternative UPACC:
Q96G25; A9IZ91; A9IZ92; Q5JUY8; Q96FQ4
Background:
Mediator of RNA polymerase II transcription subunit 8, also known as Activator-recruited cofactor 32 kDa component and Mediator complex subunit 8, plays a pivotal role in the transcription of RNA polymerase II-dependent genes. It acts as a bridge, conveying information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, facilitating the assembly of a functional preinitiation complex.
Therapeutic significance:
Understanding the role of Mediator of RNA polymerase II transcription subunit 8 could open doors to potential therapeutic strategies.