Focused On-demand Library for tRNA (uracil-5-)-methyltransferase homolog B

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.

Our library distinguishes itself through several key aspects:

  • The Receptor.AI platform integrates all available data about the target protein, including past experiments, literature data, known ligands, structural information and more. This consolidated approach maximises the probability of prioritising highly relevant compounds.
  • The platform uses sophisticated molecular simulations to identify possible binding sites so that the compounds in the focused library are suitable for discovering allosteric inhibitors and the binders for cryptic pockets.
  • The platform integrates over 50 highly customisable AI models, which are thoroughly tested and validated on a multitude of commercial drug discovery programs and research projects. It is designed to be efficient, reliable and accurate. All this power is utilised when producing the focused libraries.
  • In addition to producing the focused libraries, Receptor.AI provides services and end-to-end solutions at every stage of preclinical drug discovery. The pricing model is success-based, which reduces your risks and leverages the mutual benefits of the project's success.







Alternative names:

TRM2 homolog B; rRNA (uracil-5-)-methyltransferase TRMT2B

Alternative UPACC:

Q96GJ1; A6NDG5; A6NEI9; A6NMG6; Q5JPF0; Q5JVY6; Q96HU7; Q96IH9; Q9H9K2


tRNA (uracil-5-)-methyltransferase homolog B, also known as TRM2 homolog B and rRNA (uracil-5-)-methyltransferase TRMT2B, is a mitochondrial S-adenosyl-L-methionine-dependent methyltransferase. It plays a crucial role in the post-transcriptional modification of tRNAs and 12S rRNA, specifically catalyzing the formation of 5-methyl-uridine at position 54 in all tRNAs and position 429 in 12S rRNA. This modification process is essential for the proper functioning of mitochondrial RNA.

Therapeutic significance:

Understanding the role of tRNA (uracil-5-)-methyltransferase homolog B could open doors to potential therapeutic strategies.

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